If a client complains of pain and swelling at the IV site after receiving Doxorubicin, what should the nurse do first?

Discontinuing the IV infusion is the most appropriate initial action when a client experiences pain and swelling at the IV site after receiving Doxorubicin. This medication is known for its potential to cause extravasation, which can lead to tissue necrosis if not promptly addressed. By stopping the infusion, the nurse prevents further leakage of the drug into the surrounding tissue, mitigating the risk of more severe tissue damage.

After discontinuing the infusion, the nurse can then assess the IV site for additional signs such as redness or other complications. Applying cold compresses may be helpful in managing swelling and discomfort, but this should follow the immediate action of discontinuing the infusion. Administering an antidote would only be necessary if there is specific concern about extravasation or if the provider has instructed that an antidote is needed in this situation.