What consequence may occur from abrupt discontinuation of corticosteroids?

Abrupt discontinuation of corticosteroids can lead to adrenal insufficiency, a serious condition that occurs because the body has become reliant on the external supply of corticosteroids. When corticosteroids are taken over a prolonged period, the adrenal glands reduce their own production of these hormones as they adjust to the higher levels provided from an external source. If the medication is suddenly stopped, the body may not respond by ramping up its own production quickly enough to meet physiological needs, leading to inadequate levels of cortisol in the bloodstream.

Adrenal insufficiency can manifest with symptoms such as fatigue, weakness, body aches, and even more severe consequences like cardiovascular collapse in extreme cases. The importance of tapering corticosteroid dosages rather than stopping them abruptly is critical in clinical practice in order to allow the adrenal glands time to recover and resume their normal function.