What is a common side effect of taking non-steroidal anti-inflammatory drugs (NSAIDs)?

Gastrointestinal irritation is a well-recognized side effect of non-steroidal anti-inflammatory drugs (NSAIDs). These medications, which include popular options like ibuprofen and naproxen, work by inhibiting enzymes involved in the production of prostaglandins, which play a role in inflammation and pain. However, prostaglandins also help to protect the stomach lining and maintain gastrointestinal health. When NSAIDs reduce prostaglandin levels, it can lead to irritation of the stomach lining, resulting in symptoms such as nausea, vomiting, ulcers, and gastrointestinal bleeding.

This side effect is particularly significant because it can lead to serious complications, especially in individuals who take these medications regularly or in high doses. Awareness of this risk is crucial for both patients and healthcare providers when considering pain management strategies. Other options listed, while they may be associated with certain conditions or medications, are not common side effects specifically tied to NSAIDs.