When instructing a client about the use of metronidazole, what key information should the nurse provide?

Taking metronidazole with food is important because it can help reduce gastrointestinal side effects that some patients may experience, such as nausea and abdominal discomfort. This advice encourages better tolerance of the medication, which is crucial for ensuring that patients complete their course of treatment effectively. Additionally, taking the medication with food may enhance its absorption, potentially increasing its efficacy in treating the infection.

While the other options provide important considerations related to metronidazole's side effects and usage, they do not specifically address how to enhance patient compliance and comfort during treatment. For instance, urine color changes might occur, but the patient may not need to notify the clinic unless accompanied by concerning symptoms. Sun exposure is more relevant to other medications, and stopping the medication prematurely, such as when diarrhea resolves, can lead to treatment failure or recurrence of the infection.