Which laboratory test is monitored for patients on methotrexate therapy?

When monitoring patients on methotrexate therapy, liver function tests are particularly important because methotrexate can result in hepatotoxicity. Methotrexate is an antimetabolite commonly used in the treatment of cancer and autoimmune diseases, and it can affect liver enzymes, indicating potential liver damage. Regular monitoring of these tests helps ensure that the patient’s liver is functioning adequately and that any potential liver toxicity is identified and managed early.

The other laboratory tests mentioned, while they may be relevant in the overall clinical management of a patient, are not the primary focus when monitoring the effects of methotrexate. For instance, complete blood counts are also important because methotrexate can cause bone marrow suppression leading to anemia and leukopenia, but they are not as specific as liver function tests for detecting the direct impact of methotrexate on the liver. Electrolyte panels and thyroid function tests have their significance in broader patient care but do not directly relate to the potential complications arising from methotrexate therapy. Hence, liver function tests are the most pertinent laboratory tests to monitor in this context.